PLAT and Stroke: However, the second part of the study demonstrated a long term clinical benefit of tPA treatment in AIS patients, treated within 3 h of stroke onset, as measured by “global odds ratio for a favorable outcome.” The study also reported a significant increase in symptomatic intracerebral hemorrhage (sICH) within 36 h of tPA treatment (6.4 vs. 0.6%; p < 0.001).