PLAT and androgen insensitivity syndrome: Considering the modest sample size in each of these trials, a meta-analysis was carried out involving data from EXTEND, ECASS-4:EXTEND and EPITHET trails the results of which implicate that the AIS patients with perfusion mismatch, suggesting of salvageable brain tissue, do demonstrate improved functional outcome even when the tPA was administered beyond its 4.5 h window, for up to 9 h of stoke onset (37).