Letra et al. (2012) extensively investigated the role of IRF6 in the nonsyndromic orofacial cleft (OFCs) with TA situated outside the cleft region in a cohort of 134 Brazilian patients, thereby establishing a borderline-associated IRF6 marker (rs6588860) in the subgroup of the subjects exhibiting CP and TA. Nine genomic loci and 26 candidate genes were identified in the previous literature leading to the occurrence of those two congenital disabilities (Phan et al., 2016). This evidence concerns the gene IRF6 and orofacial cleft.