Since glial activation has been reported in many neurodegenerative disorders, including PD, and this activation contribute to the disease progression (Guzman-Martinez et al., 2019; Li et al., 2019), the upregulation of PROK2 in dopaminergic neurons represents not only a local protective mechanism against neuronal death but could also play an important role in neuron-glia cross-talk. This evidence concerns the gene PROK2 and Parkinson disease.