PROK2 and Stroke: The PROK2 overexpression proved to be harmful since the exogenous PROK2 post-stroke delivery worsened the ischemic injury, whereas blocking PROK2 expression reduced the infarct volume and central inflammation and improved behavioral outcome, suggesting that impairing the PROK2 levels could be therapeutic The harmful effect of PROK2 is also supported by the signal transduction pathways activation.