-Ischemic cortex and striatum: ↑ PROK2 mRNA (Cheng et al., 2012)-PROK2 i.c.v. injection after stroke: ↑ infarct volume (Cheng et al., 2012)- PKRs antagonist: ↓ infarct volume, ↓ central inflammation and improves behavioral outcome (Cheng et al., 2012). The gene discussed is PROK2; the disease is Stroke.