The relative mRNA expressions of Caspase-3 of HF zebrafish in SYDC-H treatment group and digoxin treatment group were significantly decreased compared with those of HF zebrafish in the model control group (4.78 ± 0.06 versus 54.23 ± 5.24; 3.27 ± 0.16 versus 54.23 ± 5.24, p < 0.001). The gene discussed is CASP3; the disease is hydrops fetalis.