The mRNA relative expression of Caspase-1 and Caspase-3 of HF zebrafish in the model control group was significantly increased compared with that of HF zebrafish in the normal control group (105.95 ± 2.93 versus 1.00 ± 0.10; 54.23 ± 5.24 versus 0.65 ± 0.15, p < 0.001). The gene discussed is CASP1; the disease is hydrops fetalis.