In recent days, HMGB1 has been extensively explored in several HMGB1 mediated neurological pathologies including Epileptogenesis (Maroso et al., 2010; Paudel et al., 2019b), Parkinson’s disease (PD) (Gao et al., 2011; Angelopoulou et al., 2018), Alzheimer’s disease (AD) (Takata et al., 2004; Paudel et al., 2020a), Multiple sclerosis (MS) (Andersson et al., 2008; Paudel et al., 2019a) and ALS (Brambilla et al., 2018; Paudel et al., 2020c) and Brain injuries (Okuma et al., 2012; Paudel et al., 2020b). Here, HMGB1 is linked to multiple sclerosis.