HCRT and Anxiety: Orexin fibers and receptors are found in many of the regions of the anxiety network including the BSTDL and CeL (Peyron et al., 1998; Marcus et al., 2001) and administrations of orexins in these areas of the cEA were reported to produce anxiety-like responses (Lungwitz et al., 2012; Avolio et al., 2014).