TARDBP and amyotrophic lateral sclerosis: Furthermore, while most forms of ALS are due to pathological inclusions of TDP-43 (with some exceptions, noted in the next section), about half of all bvFTD (Neumann et al., 2006; Perry et al., 2017), most svPPA (Grossman, 2010; Josephs et al., 2011; Borghesani et al., 2020), and a portion of nfvPPA cases are due to TDP-43 (Adams-Carr et al., 2020).