Genome-wide association studies have identified polymorphisms with various levels of risk to develop AD, such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D, MS4A, MEF2C, NME8, PICALM, PTK2B, SLC24H4-RIN3, SORL1, and ZCWPW1 (Harold et al., 2009; Lambert et al., 2009; Moustafa et al., 2018). The gene discussed is PICALM; the disease is Alzheimer disease.