MAPT and Alzheimer disease: The main pathology of AD involves a higher level of extracellular amyloid-beta (Aβ) peptide in brain tissue, depositing in diffuse and neuritic plaques, and intracellular hyperphosphorylated tau (a microtubule assembly protein, p-tau) accumulating as neurofibrillary tangles (Dubois et al., 2016).