Using the χ2 test, the significant associations of AD status were found with APOE genotype and MS4A4E (rs670139), but not with PICALM (rs3851179), EPHA1 (rs11771145), CR1 (rs3818361), CR1 (rs6656401), CD33 (rs3865444), ABCA7 (rs3764650), CLU (rs9331888), BIN1 (rs744373), or CD2AP (rs9349407) (Table 2). This evidence concerns the gene CD33 and Alzheimer disease.