Furthermore, the roles of other stroke-associated genes, such as SAMHD-1, DDAH-1, HMOX1, LTC4S, ACTB, KPNA2, and JUN, in mediating stroke secondary to SARS-CoV-2 infection are required to be further explored experimental using COVID-19 patient samples or SARS-CoV-2 animal models. This evidence concerns the gene SAMHD1 and COVID-19.