Meanwhile, other stroke-associated genes, such as SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase-1 (SAMHD-1), dimethylarginine dimethylaminohydrolase-1 (DDAH-1), heme oxygenase 1 (HMOX1), leukotriene C4 synthase (LTC4S), actin beta (ACTB), and karyopherin subunit alpha 2 (KPNA2) and Jun proto-oncogene (JUN), which are potentially or directly targeted by SARS-CoV-2 may also play roles in inflammatory response and coagulopathy. The gene discussed is SAMHD1; the disease is Stroke.