Moreover, through the gene expression analysis of The Cancer Genome Atlas (TCGA; https://portal.gdc.cancer.gov/) database, we found that FAR1 expression positively correlates with ferroptosis response signature which is accompanied with high ACSL4 and low GPX4 expression levels in colorectal and breast cancers (Supplementary Fig. S4c, d). Here, GPX4 is linked to breast cancer.