Using siRNA and/or CRISPR/Cas9 approaches, we determined that reduced SKP1 or CUL1 expression induced CIN in two fallopian tube secretory epithelial (FT) cell models, a cellular precursor of HGSOC.48,49 Collectively, our data show that diminished SKP1 or CUL1 expression induces CIN, which is consistent with potential pathogenic roles in HGSOC. Here, SKP1 is linked to cervical squamous intraepithelial neoplasia.