CUL1 and cervical squamous intraepithelial neoplasia: Nonetheless, these data show that diminished SKP1 or CUL1 expression (i.e., aberrant SCF complex function) corresponds with increases in Cyclin E1 levels that collectively induce CIN, and are therefore consistent with reduced SKP1 or CUL1 expression being novel pathogenic drivers of HGSOC that are independent of genomic CCNE1 amplification.