While CCNE1 is amplified in ~10–20% of HGSOC cases28,29 and ectopic overexpression induces CIN in animal models,21 ~30–50% of all HGSOC cases exhibit increased levels of Cyclin E1 protein,28,30,31 suggesting additional mechanisms beyond genomic amplification exist to account for the elevated levels and CIN. The gene discussed is CCNE1; the disease is cervical squamous intraepithelial neoplasia.