Indeed, while Cyclin E1 protein levels are elevated in ~45–50% of HGSOC cases,30,31 genomic amplification of the Cyclin E1 (CCNE1) gene only occurs in ~20% of cases.29 This study identifies a novel mechanism whereby diminished SKP1 or CUL1 expression, and thus reduced SCF complex activity, may lead to increased Cyclin E1 protein levels that correspond with increases in CIN. The gene discussed is SKP1; the disease is cervical squamous intraepithelial neoplasia.