Using siRNA and/or CRISPR/Cas9 approaches, we determined that reduced SKP1 or CUL1 expression induced CIN in two fallopian tube secretory epithelial (FT) cell models, a cellular precursor of HGSOC.48,49 Collectively, our data show that diminished SKP1 or CUL1 expression induces CIN, which is consistent with potential pathogenic roles in HGSOC. The gene discussed is CUL1; the disease is cervical squamous intraepithelial neoplasia.