SKP1 and cervical squamous intraepithelial neoplasia: Both clones exhibited statistically significant changes in nuclear areas relative to the NT control at each timepoint, with SKP1+/− 1 primarily exhibiting decreases in nuclear areas and SKP1+/− 2 exhibiting increases in nuclear areas and nuclear area heterogeneity (Fig. 7a), which is consistent with the heterogeneous CIN phenotype (Supplementary Table SX).