CXCL2 and fibrosis: Fibrosis is generally characterised by injury to alveolar epithelial cells, activation of fibroblasts and myofibroblasts, overproduction of ECM, and dysregulation of macrophages.22 Delaying the production of chemokines and cytokines in wounds is a common source of chronic inflammation that can lead to non-resolving wounds.21 For example, Monocyte chemoattractant protein-1 (MCP-1)/CC chemokine ligand 2 and macrophage inflammatory protein 2 (MIP-2)/CXCL2 (chemokine (C-X-C motif) ligand 2) are necessary for the influx of monocytes and activation of macrophages.