CCL2 and neoplasm: In the present study, we have discovered that FL-FDC crosstalk favors tumor growth onset, and through the secretion of CCL2, as previously reported in FL BM microenvironment [40], and CSF-1 induces the recruitment of monocytes and their differentiation-polarization towards a clear M2-like protumoral phenotype, both in vitro (CD163high CD86low) and in vivo (CD206high iNOSlow), cooperating in providing long-term protumoral support.