PDCD1 and B-cell chronic lymphocytic leukemia: Within the CD8+ TEM population, EOMES expression levels were higher in PD-1+ versus PD-1− cells of both CLL and HD (Supplementary Fig. 1E), confirming the relevance of EOMES in activated T cells and suggesting that, similarly as in other tumor entities [6, 26], EOMES accumulates in exhausted T cells in CLL.