In our earlier work, mice deficient in NAIP/NLRC4 were shown to expel fewer S.Tm-infected enterocytes into the gut lumen, at least during the first 12–18 h of infection.39 Therefore, it appeared somewhat counterintuitive that here we observed epithelium loss in NAIP/NLRC4-deficient mice at 72 h p.i.. This evidence concerns the gene NAIP and infection.