This extends the findings of a previous report, which observed multiple potential cell death cascades downstream of NLRC4 upon FlaTox challenge.37 In summary, these results establish that (1) epithelial NAIP/NLRC4 drives a swift and heterogeneous enterocyte death response to reduce S.Tm tissue loads in the very first window of acute infection, but also that (2) NAIP/NLRC4-independent enterocyte dislodging could occur at subsequent stages of the infection. The gene discussed is NAIP; the disease is infection.