RIPK3 has an RIP homotypic interaction motif (RHIM) domain with which it can bind with RIPK1, DAI, TRIF, and itself.9 Typically, necroptosis involves the formation of RIPK1/3 ligands and the subsequent activation of MLKL.9 In our study, we observed increases in RIPK1, RIPK3, and MLKL in both NEC patients and model animals. Here, RIPK3 is linked to necrotizing enterocolitis.