RIPK1 and necrotizing enterocolitis: RIPK3 has an RIP homotypic interaction motif (RHIM) domain with which it can bind with RIPK1, DAI, TRIF, and itself.9 Typically, necroptosis involves the formation of RIPK1/3 ligands and the subsequent activation of MLKL.9 In our study, we observed increases in RIPK1, RIPK3, and MLKL in both NEC patients and model animals.