PCSK1 and necrotizing enterocolitis: Nec-1s is a derivative of nec-1 that functions as an allosteric inhibitor of RIPK1 in a T-loop-dependent manner.21 While nec-1 has been reported to function through mechanisms other than stabilizing RIPK1, nec-1s targets RIPK1 exclusively with the same effects as nec-1.22 In addition, nec-1s does not have the same sensitizing effect as nec-1 when used at a low dose.22 Nec-1s inhibits necroptosis by blocking the binding of RIPK1 and RIPK3,23 thereby reducing necroptosis and protecting against intestinal injury in NEC model animals.