Chen et al. showed in the bleomycin injured mouse model of pulmonary fibrosis that Gd-Hyd imaging of allysine reflected fibrogenesis and that Gd-Hyd could distinguish active fibrogenesis from stable scar, and also showed that Gd-Hyd could monitor treatment response with the pan lysyl oxidase inhibitor beta-aminopropionitrile36. This evidence concerns the gene LOX and pulmonary fibrosis.