A novel 14-gene signature comprising CCDC148, SH3RF2, CACNA1D, POLD3, PARP1, AP1M2, C4orf19, ANO1, VGLL1, SCEL, INPP4B, NET1, INSIG2 and BVES and a corresponding risk score formula were established for pancreatic cancer risk stratification and prognosis prediction. Here, INSIG2 is linked to familial pancreatic carcinoma.