PPROM pregnancies with intra-amniotic infection and sterile intra-amniotic inflammation had higher amniotic fluid FcgammaBP concentrations than did the women with colonization and with negative amniotic fluid (infection: median 85.6 ng/mL, IQR 37.3–146.0, sterile: median 41.3 ng/mL, IQR 22.5–91.4, colonization: median 12.3 ng/mL, IQR 8.0–19.8, negative 12.2 ng/mL, IQR 9.0–17.8; p < 0.0001; Fig. 1a). Here, FCGBP is linked to preterm premature rupture of the membranes.