Expression of Rab26 protects the adheren junctional integrity in acute lung injury, while loss of Rab26 results in CDH5/VE-cadherin internalization, thereby weakening the integrity of adheren junction in pulmonary microvascular endothelial cells30; similarly, expression of Rab26 may keep the endothelial/epithelial property of cancer cells, and depletion of Rab26 may enhance the motility of cancer cells. This evidence concerns the gene CDH5 and cancer.