To further access the epigenetic mechanisms responsible for the downregulation of CD47 and PD-L1 expression after LSD1 knockdown in cervical cancer cells, we obtained visualization data of histone ChIP sequencing (ChIP-Seq) from the ENCODE database (https://www.encodeproject.org/) and observed enrichment of H3K4me2 marks in the CD47/CD274 promoter region in various tumor cells (Fig. 2A). This evidence concerns the gene CD274 and neoplasm.