CXCR4 and neoplasm: Indeed, among several cytokines that regulate the tumor-bone interaction and were upregulated significantly more by KLF5KQ than by KLF5KR (SHH, WNT5A, IL11, and IL6; Fig. 7b), the induction of IL-11 was dependent on CXCR4 expression (Fig. 7e–h).