In mice bearing tibial tumors of parental PC-3 cells, in which Ac-KLF5 was induced by enriched TGF-β in the bone (Fig. 1a–f), docetaxel alone slightly suppressed tibial tumor growth, as indicated by the reduced tumor size (Fig. 8a, b); and addition of CXCR4 inhibitor AMD3100 (plerixafor) significantly sensitized the tibial tumors to docetaxel, as demonstrated by alleviated bone lesions and reduced tumor area (Fig. 8a, b). The gene discussed is KLF5; the disease is neoplasm.