KLF5 and neoplasm: These findings further indicate a role of Ac-KLF5 in metastatic growth of PCa in the bone, because both bone destruction and new bone formation occur during bone metastasis, osteoclastogenesis is a crucial event that may precede or occur simultaneously with osteoblastogenesis63, and tumor cells not only induce osteoclastogenesis but also interact with osteoblasts and osteoclasts to induce bone metastasis via the activation of multiple paracrine factors64.