In our tibial model of bone metastasis with Ac-KLF5 expression, inhibition of CXCR4 with plerixafor (i.e., AMD3100), an FDA-approved drug for non-Hodgkin lymphoma and multiple myeloma, not only suppressed bone metastatic growth but also sensitized bone metastases to the therapeutic effect of docetaxel (Fig. 8). Here, KLF5 is linked to non-Hodgkin lymphoma.