In addition to IL11, several other paracrine molecules, including SHH, WNT5A, and SHH-induced osteoblast-secreted IL-6 (Fig. 7c), were also upregulated by KLF5KQ, even though their upregulation may or may not involve direct transcriptional regulation by Ac-KLF5 or depend on the CXCL12/CXCR4 axis in PCa cells. Here, IL11 is linked to posterior cortical atrophy.