TGFB1 and neoplasm: In mice bearing tibial tumors of parental PC-3 cells, in which Ac-KLF5 was induced by enriched TGF-β in the bone (Fig. 1a–f), docetaxel alone slightly suppressed tibial tumor growth, as indicated by the reduced tumor size (Fig. 8a, b); and addition of CXCR4 inhibitor AMD3100 (plerixafor) significantly sensitized the tibial tumors to docetaxel, as demonstrated by alleviated bone lesions and reduced tumor area (Fig. 8a, b).