For example, tibial injection of PCa cells expressing the wildtype KLF5 or the KLF5KQ mutant, which mimics Ac-KLF560,61, caused significant bone metastatic lesions, that of the acetylation-deficient KLF5KR mutant did not (Fig. 2a–d). The gene discussed is KLF5; the disease is posterior cortical atrophy.