Indeed, Ac-KLF5 transactivates the CXCL12/CXCR4 chemokine axis, IL-11 cytokine signaling, and likely other paracrine molecules in tumor cells, as revealed by RNA-Seq, ChIP-Seq, and related analyses (Fig. 5a, b and Supplementary Fig. 7). This evidence concerns the gene CXCL12 and neoplasm.