Considering the established TGF-β/Ac-KLF5 signaling axis and the function of TGF-β in the induction of EMT, bone metastases, and chemoresistance, we hypothesize that Ac-KLF5 plays a crucial role in the development of chemoresistant bone metastases in PCa. Here, KLF5 is linked to posterior cortical atrophy.