For example, while EMT is a cellular process that enables tumor cells to adapt to the bone microenvironment70, EMT features have been detected in PCa bone metastases22, and TGF-β is a potent inducer of both EMT and bone metastasis69,74,75, it remains to be determined whether EMT is essential for bone metastasis of PCa. This evidence concerns the gene TGFB1 and neoplasm.