Interestingly, loss of KLF5 or interruption of KLF5 acetylation at K369 significantly attenuated tumor formation in the tibia, as the incidence of tumor formation for KLF5–/– or KLF5KR was less than that for KLF5 or KLF5KQ (Fig. 2a). The gene discussed is KLF5; the disease is neoplasm.