For example, the majority of bone metastases from PCa patients were significantly enriched for cancer cells with increased Ac-KLF5 expression (Fig. 9a, b), which, together with the causal roles of Ac-KLF5 in bone metastasis and resistance to docetaxel (Figs. 2, 8), suggests that detection of Ac-KLF5 in PCa cells, including circulating tumor cells, could help predict the occurrence of bone metastasis and chemoresistance. This evidence concerns the gene KLF5 and posterior cortical atrophy.