Mutations in NKA α-isoforms are linked to several pathologies: mutations in the ATP1A2 gene encoding for α2-NKA are linked to familial hemiplegic migraine, whereas mutations in ATP1A3 gene encoding for α3-NKA are associated with a spectrum of paroxysmal neurological phenotypes, such as alternating hemiplegia of childhood (AHC), rapid-onset dystonia Parkinsonism (RDP), capos and epilepsy disorders, that are also related to PRRT2-associated diseases13,19. Here, ATP1A3 is linked to alternating hemiplegia of childhood.