Moreover, H1299 cells showed higher invasive ability than H460 cells (Supplementary Fig. 9c), indicating that the higher the invasiveness, the greater the increase of HNRNPK mRNA and LINC00263. Consistent with the previous results, knockdown of hnRNPK and LINC00263 induced a decrease of CAPN2 mRNA in both the lung cancer cells (Fig. 8c). The gene discussed is CAPN2; the disease is lung carcinoma.