ERBB2 and gastric cancer: In our research, inhibiting of autophagy effectively increased T-DM1-induced cytotoxicity and apoptosis in vitro and in vivo, indicating that autophagy induced by T-DM1 played a cytoprotective role in HER2-positive GC cells, which is in line with the findings of Jutten B et al., suggesting that the induction of protective autophagy might contribute to the limited effect of T-DM1 on HER2-positive GC38,39.