For instance, trastuzumab emtansine (T-DM1), an ADC that contains the HER2-targeted monoclonal antibody trastuzumab with the cytotoxic molecule emtansine, can precisely deliver emtansine into HER2-positive tumor cells to achieve antitumor activity and avoid toxicity to healthy tissues11,12. Here, ERBB2 is linked to neoplasm.