We have previously shown that whereas depletion of three fine tuners in HCC: transmembrane BAX-inhibitor motif-containing 4 (TMBIM4), transmembrane emp24-like trafficking-protein 10 (Tmed10), and D-tyrosyl-tRNA deacylase 2 (Dtd2), induces cell death in HCC cells, depletion of just one or two of these does not12. The gene discussed is TMBIM4; the disease is hepatocellular carcinoma.