Among various DC subsets, conventional type 1 DCs (cDC1s) are the main cellular source of IL-12, a fundamental cytokine for anti-cancer CD8+ CTL activation, and the super promising DC subset for induction of anti-tumor immunity due to their superior capacity to uptake dying or dead cell materials and to process tumor-associated antigens for cross-presentation [24–26]. This evidence concerns the gene CD8A and cancer.