In addition, we found that transgelin-2 is physically associated with the integrin lymphocyte function-associated antigen-1 (LFA-1), which enhances the adhesion of cytotoxic T cells to intercellular adhesion molecule-1 (ICAM-1)-positive tumor target cells, such as E0771 cells, but not ICAM-1-negative B16F10 cells [17]. Here, ITGB2 is linked to neoplasm.