Further, we observed a significant reduction in CD8+ tumor-infiltrating lymphocytes (TILs) in the B16F10 tumors from Tagln2−/− DC-injected mice (WT vs. KO, 9.8 ± 1.5 vs. 1.8 ± 1.1) (Fig. 1k). This evidence concerns the gene CD8A and neoplasm.