NFKB1 and acute myeloid leukemia: In acute myeloid leukemia cells, MLN4924 inactivated CRL1/SCF to inhibit NF-κB via accumulated IκB, leading to increased ROS generation due to downregulation of Mn-SOD (superoxide dismutase), a typical NF-κB downstream gene and a major antioxidant enzyme to scavenge ROS.