MAPK1 and cancer: The role of EDA in pathological processes such as cancer has been demonstrated by the work of Manabe and colleagues who revealed the importance of EDA+ FN1 in promoting cell cycle progression through the induction of cyclin D1 expression, hyperphosphorylation of pRb, and activation of mitogen-activated protein kinase extracellular signal regulated kinase 2 (ERK2) [44].