By univariate logistic regression analysis, we found gender, age at hospitalization, age of disease onset, BDCAF, T-SPOT, fever, ESR, CRP, erythrocyte, leukocyte, HGB, NLR, SAA, C3, albumin, TCH, HDL and IL-6 were all risk factors of BS complicated with intestinal involvement. This evidence concerns the gene CRP and Bloom syndrome.