By univariate logistic regression analysis, gender, age at hospitalization, age of disease first onset, BDCAF, T-SPOT, fever, ESR, CRP, erythrocyte, leukocyte, HGB, NLR, SAA, C3, albumin, TCH, HDL and IL-6 were found all risk factors of intestinal involvement in BS patients (as seen in Table 5). The gene discussed is ALB; the disease is Bloom syndrome.