TP53 and neoplasm: For example, the miR-200 family is induced by p53 and was the first to be identified as EMT-inhibiting miRNAs, mainly through targeting the EMT-inducing TFs ZEB1/2 by posttranscriptional modification whereas ZEB1/2 can bind to the promoters of the miR-200 family to directly repress their expression, which means frequent loss of p53 and/or miR-200 family members in tumors shifts the equilibrium of reciprocal regulation among p53, miR-200, and ZEB1/2 toward the mesenchymal state, thereby conferring the tumor cells with disseminated features [39].