The largest component of ‘writers’, VIRMA, has been verified to promote cancer progression or is associated with poor survival in multiple cancer types, including liver cancer [29], gastric cancer [30] and breast cancer [20], head and neck squamous cell carcinoma (HNSC) [31], and testicular germ cell tumors (TGCT) [32] and etc. VIRMA can participate in cancer progression in an m6A-dependent manner or m6A-independent manner. The gene discussed is VIRMA; the disease is liver cancer.