In breast cancer cell lines, TBX2 interacts with EGR1 to co-repress EGR1-target genes including the breast tumor suppressor gene NDRG1. To do so, TBX2 recruits the DNA methyltransferase DNMT3B and histone methyltransferase complex components to set a repressive chromatin mark (H3K9me3) within the proximal promoter of NDRG1 [69]. The gene discussed is PRDM9; the disease is breast carcinoma.