PTK2 and neoplasm: Our previous work identified distinct roles for FAK-Y397 and FAK-Y861 phosphorylation in tumour endothelial cells where endothelial cell FAK-Y397 but not FAK-Y861 reduced tumour growth and angiogenesis, and linking these tyrosine domains to specific signaling pathways downstream of FAK and regulation of an inside out signal affecting endothelial cells surface receptor expression [17, 35].