The pro-tumoural effects of MCP-1, proliferin, TIMP-1 and soluble ICAM-1 [42–45] whilst the anti-cancer effects of IGFBP-2, endostatin and ADAMTS-1 [46–48] have been published and suggest that this secretome signature may well provide a combination of effects on cancer growth. This evidence concerns the gene IGFBP2 and cancer.