The major difference in their expression between normal and tumor cells was observed in case of proteins like L1 cell-adhesion molecule (L1-CAM), melanoma CAM (MCAM), activated leucocyte CAM (ALCAM), vascular CAM-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and integrins as well as cadherins. This evidence concerns the gene L1CAM and neoplasm.