In the current study, we used an in vitro fibrosis model based on the stimulation with TGF-β of bronchial alveolar human epithelial cells (A549) and fibroblasts from IPF patients with different length of telomere to investigate the anti-fibrotic role of MP derived from human adipose tissue mesenchymal stem cell (AT-MSC). The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.