CD8A and colitis: Moreover, a comparative analysis of CD8+CD28low Tregs from WT and APECED model 4 mice (Hubert et al., 2009) revealed that, despite equal representation and similar immunosuppressive activity, the CD8+CD28low Tregs from Aire-KO animals fail to control the onset of colitis when using adoptive cell transfer (ACT) in vivo together with colitogenic cells, a phenotypic feature of APECED patients (Pomié et al., 2011) – which is in contrast to CD8+CD28low Tregs from WT mice.