AIRE and Autoimmunity: This form features very few, if not unique, milder autoimmune manifestations (Ahonen et al., 1990; Cetani et al., 2001; Oftedal et al., 2015), and its discovery suggests that dominant AIRE mutations play a previously unrecognized role in the induction of common organ-specific autoimmune disorders (Oftedal et al., 2015).