The archetypical lycodine alkaloid huperzineA (1, Figure 1a), for example, is a potent and selective acetylcholinesterase(AChE) inhibitor and also demonstrates noncholinergic neuroprotectiveeffects.4−6 This bioactivity is of interest for the symptomatictreatment of Alzheimer’s disease and other neurodegenerativedisorders.2,4−6 The combination of interestingstructural features and noteworthy bioactivity continue to drive syntheticstudies toward Lycopodium alkaloids and their analogues.7−12. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.