FMR1 and amyotrophic lateral sclerosis: The eIF4A inhibitor hippuristanol showed that eIF4A is required for the RAN translation of CGG-repeat expansions in FMR1 in FXTAS [47] (Figure 2A) and GGGGCC-repeat transcripts in C9ORF72-ALS/FTD [91] (Figure 2B).