Suppression of RPS25 in a FXTAS Drosophila model enhanced RAN-translated protein production and associated toxicity [99], while suppression of RPS25 reduced DPR production and rescued associated toxicity in yeast, Drosophila and human C9ORF72-ALS/FTD models [102]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.