The degree of increase in the expression levels of C3, HMGB1, TGF-β1, α-SMA, and Col I in the kidney tissues of DN model + lentivirus miR-92d-3p group decreased, and the degree of decrease in the expression levels of miR-92d-3p and E-cadherin decreased compared with those in the DN model group. The gene discussed is C3; the disease is liver dysplastic nodule.