There is also evidence that the long non-coding RNA (lncRNA) TCF21 antisense RNA-inducing demethylation, called TARID transcribed by exon 3, is associated with the CGI3 methylation island and is responsible for the demethylation of the CGI1 island in TCF21 and activates TCF21 expression by inducing promoter demethylation in melanomas (26) as described in Figure 1. The gene discussed is TCF21; the disease is melanoma.