Some independent studies (Cervera et al., 2010; Osthoff et al., 2011; Orsini et al., 2012; De La Rosa et al., 2014; Neglia et al., 2019, 2020) found a beneficial effect of MBL deficiency in stroke patients, improving prognosis and reducing C3, C4, and CRP levels, as well as the proinflammatory cytokine profile, neurological deficits and extent of brain lesions, although MBL may also be necessary at later stages, for the tissue recovery process (Ducruet et al., 2011). This evidence concerns the gene MBL2 and stroke disorder.