First, ASCL1 and NEUROD1, the two master regulators extensively reported in SCLC (Jiang et al., 2009; Osborne et al., 2013; Poirier et al., 2013), did not lie in the same ‘team’, consistent with recent reports that they regulate distinct set of genes and that ASCL1high and NEUROD1high cell lines can have quite distinct chromatin landscapes too (Borromeo et al., 2016). Here, NEUROD1 is linked to small cell lung carcinoma.