A limitation of our simulations is the inability to account for the two ‘non-NE’ subtypes, SCLC-Y (YAP1high) and SCLC-P (POU2F3high), because the SCLC regulatory network simulated (Udyavar et al., 2017) does not contain YAP1 or POU2F3 as nodes. This evidence concerns the gene YAP1 and small cell lung carcinoma.