To decipher the five clusters better, we first performed K-means clustering for K = 4 for CCLE using the levels of ASCL1, NEUROD1, YAP1, and POU2F3 and observed the four clusters: SCLC-A1 (A+; n = 28), SCLC-N (N+; n = 12) and two non-NE phenotypes: SCLC-Y (Y+; n = 8) and SCLC-P (P+; n = 4) (Figure 5B,i). This evidence concerns the gene NEUROD1 and small cell lung carcinoma.