In mice, SIN3A is required for neuronal development (Gajan et al., 2016; Witteveen et al., 2016) with mutations in SIN3A associated with Witteveen–Kolk syndrome (OMIM# 613406), a neurodevelopmental disorder characterized by developmental delay and ID (Witteveen et al., 2016). Here, SIN3A is linked to neurodevelopmental disorder.