XBP1 and Alzheimer disease: Studies have also shown that Dau down-regulated caspase-3, alleviated endoplasmic reticulum stress, and had protective effects in a nematode model of AD by stimulating the IRE-1/XBP-1 signaling pathway (Pu et al., 2018); it also had a strong antioxidant effect against acute oxidative damage (Wang et al., 2020).