PNPLA3 and overnutrition: Overnutrition and sedentary lifestyle have been considered as the main causes of NAFLD [27] and genetic variants, including PNPLA3 rs738409, TM6SF2 rs58542926 and HSD17B13 rs72613567, in patients may accelerate or decelerate the progression of NAFLD [28, 29, 30].