Yan et al42 found that lncRNA HIX003209 did not directly bind to TLR2, TLR4 and NF‐κB; however, it promoted TLR4/NF‐κB expression in macrophages through the sponge miR‐6089, which was critical for the development of rheumatoid arthritis. Here, NFKB1 is linked to rheumatoid arthritis.