The dog with PDH, an adrenal tumor, and a partial suppression pattern (88‐36‐39 nmol/L [3.2‐1.3‐1.4 μg/dL]) had an invasive adrenal tumor with local thrombus formation in the vena cava, lung metastases, an enlarged contralateral adrenal gland (width 9 mm), an endogenous ACTH concentration of 1.13 pmol/L, and a normal urinary normetanephrine to creatinine ratio (95; upper reference limit 100). Here, POMC is linked to adrenal gland neoplasm.