In hepatocellular carcinoma, M2 macrophage-derived exosomes provide a niche for cell migration mediated by tumor-associated macrophages and mediate the transportation of CD11b/CD18 to activate matrix metalloproteinase-9 signaling pathway, thereby stimulating cell metastasis (Wu et al. 2020). Here, ITGB2 is linked to hepatocellular carcinoma.