However, Th2 (CCR4+CCR6-CXCR3- or GATA3+IL-4+) and regulatory T cell (Treg) (CD25highFoxP3+) CD4+ T cells were significantly expanded in patients with CKD compared with controls (Figure 2J-L; Supplementary Figure 6). The gene discussed is CXCR3; the disease is chronic kidney disease.